WebTheir results show a bona fide recurrent EWSR1-CREB3L1 fusion/rearrangement by either RT-PCR or FISH in four of their SEF cases (4/10), while the remainder SEF cases (6/10) revealed either loss of 3’ EWSR1 locus (3/10), an altogether hemizygous deletion of EWSR1 (2/10) or a negative FISH and RT-PCR result for all loci (EWSR1, FUS and CREB3L1 ... WebMar 13, 2024 · Alternatively, t (11;16)(p11;p11) translocation resulting in EWSR1-CREB3L1 is seen in less than 10% of cases [23, 24]. Of note, MUC4-negative LGFMS with FUS-CREB3L2 fusion has been described [ 25 ]. Pathology of small intestine mesenteric LGMFS have been described in 3 cases from 3 different case reports in English literature.
Recurrent EWSR1-CREB3L1 gene fusions in sclerosing …
WebEleven cases showed the presence of CREM-related fusions (EWSR1-CREM, 7; FUS-CREM, 4), while the remaining two harbored EWSR1-ATF1 fusion. Clinically, seven … WebA translocation that creates the EWSR1/NR4A3 fusion gene causes extraskeletal myxoid chondrosarcoma, which is a rare type of soft tissue tumor that usually occurs in the lower … download m4080fx
A group of sclerosing epithelioid fibrosarcomas with low-level ...
WebEWSR1 fusions occur in myxoid liposarcoma (EWSR1-DDIT3) and in low-grade fibromyxoid sarcoma and sclerosing epithelioid fibrosarcoma (EWSR1-CREB3L1/2).14 EWSR1 fusions have also been identified in nonmesenchymal tumors, including salivary clear cell carcinoma (27 clear cell EWSR1-ATF1), odontogenic tumor (EWSR1-ATF128 and mesothelioma (), … Webdetected EWSR1-CREB3L1 fusion in each lesion, which is characteristic molecular findings of SEF. One patient presented widespread distant metastases at the time of diagnosis. In the other, no tumor deposits were detected other than primary. Both patients have been alive with 30 and 10 month follow-ups, respectively. These tumors are WebJun 21, 2024 · The predominant genetic alteration in SEF is EWSR1-CREB3L1 gene fusion with only a minority of cases showing FUS-CREB3L2 fusions. 23 24 The distinction between the two is of clinical importance, as SEF tends to be more aggressive with shorter survival rate, higher metastatic potential, and greater propensity to involve deep soft tissues and … class hiking system