Eef2 pathway
WebAug 15, 2024 · Along with AMPK activation, eEF2 phosphorylation (inactivation) was observed in the cerebral cortex, but not in the liver. AMPK is known to phosphorylate eEF2K directly 12, 13 and to activate...
Eef2 pathway
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WebSep 21, 2024 · Inducers of neurogenesis (exercise, enrichment and ketamine) cause changes in cognition and depression through eEF2 dephosphorylation. The direct pathway between external stimuli and changes in cognition and depression is outlined in the figure. WebMar 1, 2024 · Alterations in the balance of inhibitory and excitatory synaptic transmission have been implicated in the pathogenesis of neurological disorders such as epilepsy. …
WebOct 1, 2013 · eEF2K-eEF2 pathway is controlled by several molecular events and cellular processes. • eEF2 has been implicated in several learning paradigms subserved by … WebJan 9, 2012 · Tubular cell HIV-infection has been reported to manifest in the form of cellular hypertrophy and apoptosis. In the present study, we evaluated the role of mammalian target of rapamycin (mTOR) pathway in the HIV induction of tubular cell protein synthesis. Mouse proximal tubular epithelial cells (MPTECs) were transduced with either gag/pol-deleted …
WebMar 29, 2024 · EEF2 phosphorylation by cyclin A-cyclin-dependent kinase 2 (CDK2) on a novel site, serine 595 (S595), directly regulates T56 phosphorylation by eEF2K. eEF-2 … WebNov 1, 2024 · The eEF2 pathway is involved in neurological processes and diseases such as Alzheimer’s disease, where it was found that amyloid-β oligomers activate eEF2K, …
WebSep 18, 2024 · Recent evidence indicates that the AMP-activated protein kinase (AMPK)/eukaryotic elongation factor-2 kinase (eEF2K)/eukaryotic elongation factor-2 (eEF2) pathway was implicated in synaptic plasticity in AD. Therapeutic strategies for AD treatment are currently limited.
WebPlasmid pYES260-sc.eEF2 K509A from Dr. Pal Falnes's lab contains the insert EFT1/EFT2 and is published in J Biol Chem. 2014 Oct 31;289(44):30499-510. doi: 10.1074/jbc.M114.601658. Epub 2014 Sep … breeanna porcelain instagramWebMar 21, 2024 · EEF2 (Eukaryotic Translation Elongation Factor 2) is a Protein Coding gene. Diseases associated with EEF2 include Spinocerebellar Ataxia 26 and Diphtheria. … couch from back angleWeb(3) EEF2. In an in vitro study, silencing of eEF2 expression increased mitochondrial elongation, cellular autophagy, and cisplatin sensitivity. Moreover, eEF2 was sumoylated … couch from american freightWebJul 1, 2024 · To explore the interplay between the eEF2 pathway and CaMKII in the context of depression, we first injected ketamine (5 mg/kg body weight [b.w.], intraperitoneal [i.p.]) and investigated whether it produces an antidepressant effect in normal C57BL/6 mice in a depressive situation. couch from behind cartoonWebApr 28, 2010 · We also show that synaptic activity-dependent spine maturation and dendritic BDNF protein expression depend on mGluR/EF2K-induced eEF2 phosphorylation. We propose that the eEF2K/eEF2 … couch from american leatherWebSep 21, 2024 · Figure 1. eEF2/eEF2K pathway regulates neurogenesis and DG-dependent behavior in the mature brain (A) Outline of the experiment and steady-state deep … breeanna webbWebMar 5, 2024 · Overall, we conclude that the eEF2k/eEF2 pathway is up-regulated during disuse muscle atrophy, which impacts protein synthesis initiation by modulating p70S6k activity through the regulation of MAFbx/atrogin-1 … breeanna wolford